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DISEASE ASSOCIATION STUDIES | ||
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Celera is conducting disease association studies to identify genetic markers linked to specific diseases for incorporation into new diagnostic products. Our genotyping studies compare genetic samples from people with a disease (cases) to samples from healthy individuals (controls) to identify associations between genetic variations known as Single Nucleotide Polymorphisms (SNPs) and diseases. We are seeking to identify SNPs that serve as genetic markers for a specific disease, including:
Other studies are analyzing gene expression patterns to better understand disease progression or response to therapy; gene expression studies include:
Proprietary database of novel SNPs - Knowing where to look for markers is essential. Through the Applera Genomics Initiative we have identified more than 45,000 novel, functional SNPs in genes and coding regions. This is more than the total number of known functional SNPs in public databases. Industrial-scale discovery tools - Our ability to conduct genotyping, gene expression analysis and ribotyping studies in multiple disease areas with thousands of samples is supported by strong bioinformatics and statistical genetics knowledge. Large numbers of samples - For statistical significance, each study analyzes genetic samples from hundreds of individuals. Through our disease association collaborations we have access to samples that are well-characterized and were collected from people who consented to their use for genetic analysis. Replication of results - Before the results are announced, each study is repeated using a different sample set. This helps to confirm that the genetic variations are statistically significant and not just a chance result in one specific group of individuals.
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