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RECENT PUBLICATIONS | ||
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Celera is conducting disease association studies to identify genetic markers linked to specific diseases for incorporation into new diagnostic products.
Celera has discovered and replicated a number of novel genetic markers associated with common, complex diseases. Some of the findings which have been recently published or presented include:
Analysis of Families in the Multiple Autoimmune Disease Genetics Consortium (MADGC) Collection Psoriasis A Large-Scale Genetic Association Study Confirms IL12B and Leads to the Identification of IL23R as Psoriasis-Risk Genes Celera Identifies Two Genetic Variations Predisposing Individuals to Increased Risk for Psoriasis Rheumatoid Arthritis A Candidate Gene Approach Identifies
the TRAF1/C5 Region as a Risk Factor
for Rheumatoid Arthritis PTPN22 Genetic Variation: Evidence for Multiple Variants Associated with Rheumatoid Arthritis Association of the PTPN22 C1858T single-nucleotide polymorphism with rheumatoid arthritis phenotypes in an inception cohort Arthritis Foundation Names PTPN22 association as one of the Top 10 Arthritis Advances of 2004 - December 2004 A Missense Single-Nucleotide Polymorphism in a Gene Encoding a Protein Tyrosine Phosphatase (PTPN22) Is Associated with Rheumatoid Arthritis - 2004 Annual European Congress of Rheumatology (EULAR)- June 10, 2004 - Berlin, Germany Cardiovascular Disease Iakoubova et al., (2008) Association of the Trp719Arg Polymorphism in Kinesin-Like Protein 6 With Myocardial Infarction and Coronary Heart Disease in 2 Prospective Trials: The CARE and WOSCOPS Trials. Shiffman et al., (2008) A Kinesin Family Member 6 Variant Is Associated With Coronary Heart Disease in the Women’s Health Study. Iakoubova et al., (2008) Polymorphism in KIF6 Gene and Benefit From Statins After Acute Coronary Syndromes: Results From the PROVE IT-TIMI 22 Study. Shiffman et al., (2007) Association of Gene Variants With Incident Myocardial Infarction in the Cardiovascular Health Study. Bare et al., (2007) Five common gene variants identify elevated genetic risk for coronary heart disease. Luke et al., (2007) A Polymorphism in the Protease-Like Domain of Apolipoprotein(a) Is Associated With Severe Coronary Artery Disease. Morrison et al., (2007) Prediction of Coronary Heart Disease Risk using a Genetic Risk Score: The Atherosclerosis Risk in Communities Study. Iakoubova et al., (2006) Asp92Asn Polymorphism in the Myeloid IgA Fc Receptor Is Associated With Myocardial Infarction in Two Disparate Populations. Shiffman et al., (2006) Gene Variants of VAMP8 and HNRPUL1 Are Associated With Early-Onset Myocardial Infarction. Shiffman et al., (2005) Identification of Four Gene Variants Associated with Myocardial Infarction. Am. J. Hum. Genet. 77:596-605. Replicated Association of a Purinergic Receptor Variant With Risk of Myocardial Infarction - March 8, 2005 A Polymorphism in the Metabotropic Glutamate Receptor 8 Gene is Strongly Associated with Myocardial Infarction in Two Independent Studies - March 6, 2005 Replicated Associations of Genetic Variants With Coronary Artery Disease And Myocardial Infarction
5th World Stroke Congress - June 25, 2004 - Vancouver, BC International Vascular Biology Meeting - June 3, 2004 - Toronto, Canada Novel Genetic Markers Associated with Risk of Myocardial Infarction From a Genomic Scale Scan of Putative Functional Polymorphisms American College of Cardiology - March 8, 2004 - New Orleans, LA Novel Genetic Markers Associated with Myocardial Infarction: A Genomic Scale Scan of Putative Functional Polymorphisms 13th International Symposium on Atherosclerosis - September 30, 2003 - Kyoto, Japan Deep Vein Thrombosis Gene Variants Associated With Deep Vein Thrombosis Stroke Evaluation of the Paraoxonases as Candidate Genes for Stroke CENTRAL NERVOUS SYSTEM DISEASES Alzheimer's Disease Li et al., (2007) Evidence that Common Variation in NEDD9 is Associated with Susceptibility to Late-onset Alzheimer's and Parkinson's Disease Evidence for novel susceptibility genes for late-onset Alzheimer's disease from a genome-wide association study of putative functional variants DAPK1 variants are associated with Alzheimer’s disease and allele-specific expression Ubiquilin 1 Polymorphisms Are Not Associated with Late-Onset Alzheimer’s Disease A Scan of Chromosome 10 Identifies a Novel Locus Showing Strong Association with Late-Onset Alzheimer Disease The BDNF val66met polymorphism is not associated with late onset Alzheimer’s disease in three case–control samples - Genetic Association of the APP Binding Protein 2 Gene (APBB2) with Late Onset Alzheimer Disease Association of late-onset Alzheimer’s disease with genetic variation in multiple members of the GAPD gene family 9th International Conference on Alzheimer's Disease and Related Disorders
- July 21, 2004 - Philadelphia, PA Association of ABCA1 with late-onset Alzheimer’s disease is not observed in a case-control study Parkinson's Disease Genetic Evidence for Ubiquitin-Specific Proteases USP24 and USP40 as Candidate Genes for Late-Onset Parkinson Disease A Case-Control Association Study of the 12 Single-Nucleotide Polymorphisms Implicated in Parkinson Disease by a Recent Genome Scan CIRRHOSIS AND HEPATITIS C INFECTION/LIVER DISEASES Guo et al., Functional Consequences of Single Nucleotide Polymorphisms of Toll-like receptor 4 on Hepatic Stellate Cells Huang et al., Multiple Genetic Markers In TLR4 Region Are Associated With Cirrhosis Risk In CHC Patients Huang et al., A 7 gene signature identifies the risk of developing cirrhosis in patients with chronic hepatitis C Cargill et al., A Large-Scale Genetic Association Study Confirms IL12B and Leads to the Identification of IL23R as Psoriasis-Risk Genes Huang et al., A Multi-gene Signature Accurately Predicts the Risk of Bridging Fibrosis/Cirrhosis in Patients with Chronic Hepatitis C Identification of Two Gene Variants Associated With Risk of Advanced Fibrosis in Patients With Chronic Hepatitis C Association of Fibrosis Risk in HCV Patients with a Missense SNP in Gene CPT1A - 2005 Novel Genetic Markers Associated With Risk Of Non-Alcoholic Steatohepatitis In Patients With Non-Alcoholic Fatty Liver Diseases - May 2005 Identification of Novel Genetic Markers Associated with Fibrosis Progression Risk in HCV Patients - 2004 Gene Expression Profiles of Patients with Chronic Hepatitis C (CH-C) Treated with Pegylated Interferon alfa-2b and Ribavirin (PEG-IFN/RBV) Gene Expression Profiles of Patients with Chronic Hepatitis C (CH-C) Treated with Pegylated Interferon alfa-2b and Ribovirin (PEG-INF/RBV) Extraction of HCV-RNA from Plasma Samples Using the Abbott m1000 10th International Meeting on Hepatitis C Virus and Related Viruses - December 5, 2003 - Kyoto, Japan Human Papillomavirus (HPV) A rapid method for detection of oncogenic HPV types in cervical samples Breast Cancer Data Validating Its Metastasis Score as a Molecular Prognostic Tool in Breast Cancer An RT-PCR-based multi-gene prognostic signature predicts distant metastasis of node negative, ER positive breast cancer from FFPE sections. Translating Cancer Markers into Diagnostics Assays - American Association for Cancer Research – Oncogenomics 2005 24th Congress of the International Association for Breast Cancer Research - November 3, 2003 - Sacramento, CA Colon Cancer CD133/Prominin-1 Is A Novel Antibody Therapeutic Target in Pancreatic, Gastric and Hepatocellular Cancers Proteomic analysis of colorectal tumor cells identifies CD133/Prominin-1, a
cancer stem cell marker, as a monoclonal antibody therapeutic candidate Lung Cancer Lung cancer biomarkers identified through mass spectrometry-based proteomic discovery from tissue and cell lines The Use of Mass Spectrometry Based Proteomics to Identify Cell Surface Proteins Applicable for Monitoring Drug
Resistance, Response and Therapeutic Targeting
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