Also known as cerebrovascular accident, stroke occurs when an artery that carries oxygen and nutrients to the brain is blocked (ischemic) or ruptured (hemorrhagic). The affected area cannot get nutrients and oxygen resulting in the death of brain cells. Stroke is a common cause of morbidity and death with 700,000 events and 270,000 deaths per year in the United States, and it leaves many victims permanently disabled. Celera has discovered genetic variants that predict an increased risk for ischemic stroke. We are currently studying their role in predicting whether a patient may benefit from imaging to detect sub-clinical disease or from preventive treatment with statins, endarterectomy or stenting. Genetic tests that classify a greater risk of stroke might conceivably add much to patient education and public policy in mitigating the morbidity and mortality of ischemic strokes.